The influence of fillers on theophylline release from clay matrices

Abstract: The objectives of this study were to investigate the suitability of magnesium aluminium silicate (MAS) (Veegum®) to control drug release of a model drug, theophylline, from tablet matrices. To this end, the performance of three commonly used fillers namely: lactose, microcrystalline cellulose (Avicel PH102; MCC), and pre-gelatinized starch, Starch 1500 PGS), were evaluated against Veegum®. The physico-mechanical properties of the tablet matrices were studied along with dissolution studies to determine the effect of single or binary mixtures of the excipients on the drug release pattern. A DSC hydration methodology was also employed to characterize the states of water present in the tablet matrices and to determine any impact on drug release. Formulations containing MAS alone produced compacts with the lowest hardness (4.5 kp) whereas formulations containing MCC alone produced the hardest tablets (17.2 kp). Dissolution studies suggested that matrices containing MAS alone released the theophylline quickest as compared to lactose, MCC or PGS. It was difficult to establish a trend of the bound and free water states in the tablet matrices; however the formulation containing only MAS had the highest bound water at 29 %. The results therefore show that theophylline does not interact with MAS. As such the dominant factor in controlling drug release using MAS requires interaction or intercalation with a cationic drug. In the absence of this however, other excipients can play a role in controlling drug release. Keywords: Veegum, clay matrices, DSC hydration, Magnesium aluminium silicate, filler

Supply Chain Efficiency of Environmentally Friendly Microalgae-Based Biodiesel Production

Environmentally friendly algae-based biodiesel production includes biofuel extraction that represents a technological process which inflicts minimal damage to the environment or does not harm it. Biodiesel that is almost completely based on renewable resources can be utilized as one of the most promising biofuels, and it is environmentally safer than petrol-diesel for several reasons such as: 1. Microalgae have high photosynthesis efficiency and can grow very fast; 2. Microalgae can be cultivated without occupying farmlands, and thus it is possible to reduce the potential damage to the agricultural ecosystem and the traditional food webs; 3. Fresh water is not essential and nutrients can be supplied by wastewater and CO2 by gas combustion during cultivation; 4. Microalgae can be collected very quickly, obviously accelerating the biodiesel production process; 5. The property of their uniform cell structure with no bark, stems, branches or leaves make the commercial production attractive, thus making the operation and control of reproduction conditions much more practical; 6. The general properties as well as the physical biodiesel fuel properties from algae oil (e.g. density, viscosity, acid value, heating value, etc.) are comparable to those of fuel diesel. This paper investigates in detail this option presenting advantages, but also existing limits and gaps. Undoubtedly, incorporating the principles of supply-chain management enabled by information technology (IT) systems to support these processes is a more effective and efficient option to enhance the efficiency of algae-based biodiesel production

Molecular responce of Atlantic cod's (Gadus morhua L.) cypia, prolactin and Zona radiata genes upon exposure to polychlorinated biphenyls

A molecular response study was conducted to determine whether Polychlorinated Biphenyl or PCB (Clophen A40) had an effect on the induction of the zona radiata, prolactin and cytochrome P4501A (CYP1A) mRNAs in matured Atlantic cod (Gadus morhua). A total of 127 fishes were maintained under natural photoperiod in tanks and fed with wet pellets containing Clophen A40. RNA samples were taken from the gonads, pituitary and the liver from day 0, 48 and 105 after sacrificing the fish and stored at -20OC prior to analysis. Analysis of gene induction by Northern hybridization assay showed the induction of prolactin and CYP1A in the pituitary and the liver tissues respectively after PCB treatment. The induction was found to be sex, age and seasonal specific. Males had greater gene expression than the females. There was however, no observed differences between the controlled and exposed fishes in terms of zona radiata gene expression. Although the picture is far from complete, the findings demonstrate the potential of using gene induction as a biomarker of aquatic pollution.Keywords: Cytochrome P4501A, Biomarker, Gene expressio

Benefit-cost analysis of electronic claims processing under Ghana's National Health Insurance Scheme.

OBJECTIVE: The aim of this study was to evaluate the benefit-cost of E-claims. A benefit-cost analysis was used to evaluate the efficiency of E-claims from the perspective of the providers and the purchaser. DESIGN: A benefit-cost analysis approach was taken for this economic evaluation. Furthermore, we estimated the incremental benefit-cost ratio (IBCR) of the intervention under assessment. PARTICIPANTS: Purchasers and healthcare providers of the National Health Insurance Scheme (NHIS) of Ghana were the study population. RESULTS: The analysis was stratified according to providers and purchaser. Cost incurred in processing claims electronically and manually were estimated by assessing the resource use and their corresponding costs. Sensitivity analysis was conducted to assess the robustness of the results to variations in discount rate and proportions of claims processed under E-claims compared with paper claims. The combined sample of providers and purchaser made incremental gains from processing claims electronically. The IBCR was -19.75, 25.56 and 5.10 for all (sample) providers, purchaser and both providers and purchaser, respectively. When projected for the 330 facilities submitting claims to the NHIS claims processing centre (CPC) as at December 2014, the IBCR were -35.20, 25.56 and 90.06 for all providers, purchaser and both providers and purchaser. The results were sensitive to the discount rate used and proportions of E-claims compared with paper claims. CONCLUSION: Electronic processing of claims is more efficient compared with manual processing, hence provide an economic case for scaling it up to cover many more healthcare facilities and NHIS CPCs in the Ghana

Economic burden of caregiving for persons with severe mental illness in sub-Saharan Africa: A systematic review

© 2018 Addo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Over the past two decades, the focus of mental health care has shifted from institutionalisation to community-based programs and short hospital stays. This change means that there is an increased role for caregivers, mostly family members, in managing persons with mental illness. Although there is evidence to support the benefits of deinstitutionalisation of mental health care, there are also indications of substantial burden experienced by caregivers; the evidence of which is limited in sub-Saharan Africa. However, knowledge of the nature and extent of this burden can inform the planning of mental health services that will not only benefit patients, but also caregivers and households. Objective To systematically review the available evidence on the economic burden of severe mental illness on primary family caregivers in sub-Saharan Africa. Methods A comprehensive search was conducted in Pubmed, CINAHL, Econlit and Web of Science with no date limitations up to September 2016 using keywords such as "burden", "cost of illness" and "economic burden" to identify relevant published literature. Articles were appraised using a standardised data extraction tool covering themes such as physical, psychological and socioeconomic burden. Results Seven papers were included in the review. Caregivers were mostly family members with a mean age of 46.34, female and unemployed. Five out of seven studies (71%) estimated the full economic burden of severe mental illness on caregivers. The remainder of studies just described the caregiver burden. All seven papers reported moderate to severe caregiver burden characterised by financial constraint, productivity loss and lost employment. The caregiver’s level of income and employment status, severity of patient’s condition and duration of mental illness were reported to negatively affect the economic burden experienced by caregivers. Conclusion There is paucity of studies reporting the burden of severe mental illness on caregivers in sub-Saharan Africa. Further research is needed to present the nature and extent of this burden to inform service planning and policymaking

Industrial Transformation Roadmap for Digitalisation and Smart Factories:The Danish SMEs Model

Today only some sections of the supply chain are digitalized, but some companies are also already far with Industry 4.0, where the virtual factory and the physical factory work closely together (digital twin). Industry 4.0, which started in Germany among the large OEMs, seems to have not resonated much with SMEs. There is an imminent challenge of coming up with a feasible transformation roadmap which will resonate effectively and efficiently with SEMs as they are the core backbone of every performing economy. This research investigates Smart Factories/Industry 4.0 in the Danish SMEs model perspective. This research's main objectives are to develop a feasible roadmap in the form of a conceptual framework for easy industrial transformation to the digitalizing and smart way of (doing things) developing products and/or services. This research employs quantitative research methods such as surveys and interviews where applicable as well as a literature review in the SMEs perspective. Previous research has shown that the digital evolution coined as Industry 4.0 was started among large companies. However, this initial precedence has not resonated very much with all-inclusive industrial evolution, especially within the SMEs perspective. The main industrial implication will be the definition of a clear feasible roadmap for what this research terms as an industrial transformation process - "digital change management process - Industry 4.0/Smart factory" in the industrial SMEs perspective - the Danish Model. This research seeks to propose a conceptual smart factory roadmap in an Industry 4.0 perspective, which could be adopted among manufacturing SMEs to effectively, and efficiently transform their production operations. The Danish model perspective or angle of Industry 4.0.</p

Advanced Animal Track-&-Trace Supply-Chain Conceptual Framework: An Internet of Things Approach

Information and data transmission, as well as total visibility in terms of supply chain track-&-trace, is seriously lacking in current industrial logistics-&-supply-chain management activities. This paper proposes the application of RFIDs and the Internet of things’ enterprise systems architecture to, propose a low-cost feasible cloud solution. This solution would keep track of health history, birth records, ownership history and track location of each animal by using an electronic solar-powered tag instead of the current passive ear tags. This paper employs GPRS, GSM and the Google Earth function along with RFIDs to design an enhanced proposed enterprise system-architecture framework in the form of a business process model. Various areas such as e-health, e-commerce, and cloud-based manufacturing have been revolutionized by discoveries in digitized practices. Advancements in the Internet of things led to the advent of asset tracking systems, condition monitoring and various intelligent systems that exchange data over the cloud. Farmers are very vulnerable to stock theft, straying animals and high business risks due to poor animal health management practices. Existing tracking systems have high ownership costs since some of them rely on GSM network providers whose services are costly for farmers. Innovations in digitized systems continue to add more value to businesses and individuals across broad range sectors. Authors of this paper propose a low-cost intelligent animal tracking system for an African free-ranging environment. Economies worldwide are ever becoming digital and animal husbandry practices stand to benefit from this digitisation approach

(2,3,7,8,12,13,17,18-Octa­ethyl­por­phin­ato)(trifluoro­methane­sulfonato)iron(III)

The title compound, [Fe(CF3O3S)(C36H44N4)], is an iron(III) porphyrin complex with the trifluoro­methane­sulfonate anion as an axial ligand. The Fe atom is displaced by 0.219 (2) Å toward the trifluoro­methane­sulfonate anion from the 24-atom mean plane of the porphyrin, resulting in a distorted FeN4O square-based pyramidal geometry. One ethyl­ene group is disordered over two orientations in a 0.502 (6):0.498 (6) ratio

[5,10,15,20-Tetra­kis(4-meth­oxy­phen­yl)porphyrinato-κ4 N,N′,N′′,N′′′](trifluoro­methane­sulfonato-κO)­iron(III)

The title compound, [Fe(CF3O3S)(C48H36N4O4)], is a five-coordinate iron(III) porphyrin complex with a trifluoro­methane­sulfonate anion as an axial ligand. The FeIII atom is displaced by 0.40 (1) Å towards the trifluoro­methane­sulfonate anion from the 24-atom mean plane of the porphyrin. The average Fe—Np distance is 2.044 (2) Å and the Fe—O distance is 2.001 (2) Å

Genome-wide profiling of uncapped mRNA

Gene transcripts are under extensive posttranscriptional regulation, including the regulation of their stability. A major route for mRNA degradation produces uncapped mRNAs, which can be generated by decapping enzymes, endonucleases, and small RNAs. Profiling uncapped mRNA molecules is important for the understanding of the transcriptome, whose composition is determined by a balance between mRNA synthesis and degradation. In this chapter, we describe a method to profile these uncapped mRNAs at the genome scale